iNOS/NO is required for IRF1 activation in response to liver ischemia-reperfusion in mice
Abstract Background Ischemia and reperfusion (I/R) Gas Door Cover induces cytokines, and up-regulates inducible nitric oxide synthase (iNOS), interferon regulatory factor-1(IRF1) and p53 up-regulated modulator of apoptosis (PUMA), which contribute to cell death and tissue injury.However, the mechanisms that I/R induces IRF1-PUMA through iNOS/NO is